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After 1 year of follow-up, the mean weight loss from baseline with semaglutide 2.4 mg and tirzepatide was 14.6 and 17.2 kg, respectively, with percent weight loss of 14.1% and 16.5%

GLP-RT is commonly used in laboratory research to investigate signaling between three metabolic hormone receptors: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

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