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Systemic antifungal agents for cutaneous fungal infections
doi: 10.1016/j.jpeds.2017.10.046
In turn, the impairment in -oxidation can shift the metabolism of VPA toward predominantly peroxisomal -oxidation, resulting in excessive production and accumulation of -oxidation products, including 4-en-VPA a metabolite that is incriminated in VPA-induced hepatotoxicity
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