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In receptor-binding studies, tirzepatide demonstrated a high affinity for the GIPR, comparable to that of native GIP, while its affinity for the GLP-1R is approximately 18- to 20-fold weaker than that of native GLP-1 [33]

However, human biology differs significantly

GLP-1 Medication Safety Profile During Lactation: What Research Shows Current evidence is limited and categorized by medication type
