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In the first trial, liraglutide lowered weight by 12 pounds and improved glucose tolerance relative to placebo over 4 months in 103 patients with schizophrenia spectrum disorders (Larsen JR et al, JAMA Psych 2017;74(1):719728)
Moreover, considering the CVD continuum where it progresses from risk factors such as diabetes to atherosclerosis and CHD, until it leads to heart failure or death [46], GLP-1 analogues act in different stages of this pathophysiological process (see Fig

10.1186/s12937-024-01048-7 88 WyshamC.BlevinsT.ArakakiR.ColonG.GarciaP.AtissoC.et al (2014)
