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K., Smith, J., Ji, H.-F., Brooks, A
Neither their approaches, which relies on the production of isotope enriched CO2, nor the nitrogen balance studies take into account the unique role of the SAA (sulfur amino acids), to provide S for sulfation
The absence of regulatory guidelines around dosage, frequency, and duration further complicates safety evaluations
NSC48160, a Kirsten rat sarcoma viral oncogene homolog (KRAS) inhibitor, indirectly suppresses the NRF2-SLC7A11-GPX4 axis by disrupting the tricarboxylic acid (TCA) cycle, thereby promoting ferroptosis in KRAS-mutant HCC models [47]
